Low dose single bolus heparin makes particular sense if early sheath removal is performed. Bolus dose bolus dose for patients who have not received heparin within the last 6 hours. Round to the nearest 50 units standard infusion bag. Heparins, including unfractionated heparin and a variety of low molecular weight lmw heparin products, are used extensively as anticoagulants. Resume iv heparin infusion per vte protocol without a bolus when aptt is protocols were used for all the patients. Discontinue heparin if platelets decrease by 50% from baseline and proceed with hit protocol. Guideline for anticoagulation and prophylaxis using low.
Fortythree patients were managed postoperatively with a low dose intravenous heparin infusion maryland low dose intravenous heparin infusion protocol. The learning package was adapted from the powh intravenous heparin infusion learning package developed by sarah lyons cnc venous thromboembolism vte prevention in january 2014 as part of initiatives undertaken by the powh heparin and other anticoagulants high risk medicine working party. The dose of alteplase is given in two parts see table 1 for details. Thrombolytic alteplase tpa orders for pulmonary embolism pe page 1 of 2. In 1998, the us fda approved the low molecular weight heparin. Dose adjustments to both the bolus dose and the initial infusion dose may be. Low dose ketamine intravenous infusion, a doses ketamine still acts as an excellent anal relatively new technique in clinical practice, is gesic. Use total body weight in all cases use adjusted body weight if 30% over ibw. Achievement of anticoagulation by using a weightbased heparin dosing protocol for obese and nonobese patients.
Rx ultra low heparin infusion protocol nurse adjusts heparin dose using a standardized algorithm to maintain antixa between 0. Guideline for anticoagulation and prophylaxis using low molecular weight heparin lmwh in adult inpatients. Goal ptt 79118 seconds ptt rebolus or hold rate adjustment recheck ptt. Use the following nomograms for adjusting heparin drip rates. Heparin infusion orders should include the dose written as unitskghour and the corresponding mlhour rate. If inr is therapeutic or supratherapeutic, discuss with attending for optimal timing of heparin infusion initiation. Adjusted versus fixed dose subcutaneous heparin in the prevention of deep vein thrombosis after total hip. Blood samples were collected at various times and acute physiology and chronic health evaluation apacheii scores were. Adult heparin drip protocol ventura county, california. Because the anticoagulant effect of warfarin is delayed, heparin is administered for rapid anticoagulation. For patients on heparin unfractionated or low molecular weight. Time since last heparin dose dose of protamine heparin 30 60 minutes 0. Therapeutic unfractionated heparin ufh infusion procedure uncontrolled document when printed published.
This also means enhanced patient comfort, short hospital stay, and reduced cost. Additional citations were retrieved from the bibliography. Lowdose heparin use and the patency of peripheral iv. Only the heparin dose given over the last 34 hours needs to be included in the protamine dose calculation. Very high doses of heparin are cleared predominantly through the slower nonsaturable mechanism of clearance. Nevertheless, most vte treatment trials incorporated a fixed dose initial heparin infusion regimen of 5000 unit bolus followed by infusion of approximately 0 unitsh 7. Unintended concomitant use of two heparin products unfractionated heparin and lmw hepa. Regional anesthesia in the patient receiving antithrombotic or. Therapeutic dosing of unfractionated heparin uw health. Select desired weight preference based on local protocol. Low dose heparin reduces the risk of venous thrombosis and fatal pe by 60% to 70%. Total units in iv bag unitshour total volume ml x mlhour your patient has a dvt is ordered for a heparin infusion to start at 18 unitskghour per the practitioners order.
Massive and submassive pulmonary embolism algorithm. Lowdose heparin as treatment for early disseminated. Dosage and administration must be individualized according to the results of suitable laboratory tests. Heparin infusion guidelines anticoagulation services. This is a new protocol that satisfies a therapeutic goal hptt desired by numerous prescribers. Order standard heparin infusion with starting rate defaulted based on. Adult patients requiring iv unfractionated heparin anticoagulation therapy. Low dose intravenous heparin ldivh infusion using the maryland protocol was recently shown to reduce clinical vasospasm and vasospasmrelated infarction. Reversal of anticoagulants at ucdmc uc davis health. Obtain ptt 6 hours after initiation of heparin and after any subsequent changes until therapeutic x 2, then every am.
Low dose heparin for routine ptca can be considered a safe and established policy facilitating the use of modern potent antiplatelet agents in case of need. Start oral anticoagulant 0 to 2 hours before the time the next dose of heparin was to have been administered. Intravenous iv ufh has an immediate onset of action but requires monitoring and infusion rate adjustments in order to achieve a targeted therapeutic range5. Unfractionated heparin infusion protocol hospital quality institute. Flushing frequencies and use of heparin when administering pediatric medications the sash technique should be used. If dvtpe selected above, fill in the section below. Guidance for the practical management of the heparin. Therapeutic dosing of unfractionated heparin adult emergency departmentinpatient clinical practice guideline. There are however wide variations in the used either to supplement light anaesthesia or as recommended dose for the intravenous infusions a sole anaesthetic agent. For use when anticoagulation therapy with low molecular weight.
If inr is subtherapeutic, start heparin infusion per protocol. Heparin dosing protocols medical city dallas hospital. Protamine, given as a slow iv infusion 1 % solution, may largely neutralize heparin. Therapeutic dosing of unfractionated heparin adult. To standardize heparin anticoagulation therapy at university hospital.
Reduction of mortality in general medical inpatients by low dose heparin prophylaxis. Check aptt 1 hour after the iv tpa infusion completion, then q 1 hour as needed if first aptt is still too high 2. Round ptt to the nearest whole number if lower initial infusion rate with the. Once the prescriber orders the heparin protocol, the nurse takes the following steps. Cath lab, the prescriber should sign in the administration chart to signify this.
Heparin dosing protocols affinity health system globalrph. If a patient is eligible for thrombolysis, stop the iv unfractionated heparin ufh infusion or low molecular weight heparin lmwh 3. Continuous infusion of lowdose unfractionated heparin. Heparin in a fixed low dose of 5000 u sc every 8 or 12 hours is an effective and safe form of prophylaxis in medical and surgical patients at risk of venous thromboembolism. Initiate heparin infusion when next enoxaparin dose is expected to be given. The heparin group received a low dose of heparin for 57 days, while the other group received only saline. This guideline provides recommendations regarding best practice for anticoagulation treatment and prophylaxis of venous thromboembolism for adult inpatients in queensland health facilities using low molecular weight heparins.
A metaanalysis comparing iv heparin to dose adjusted sc heparin initial dose 5000 units iv then 17,500 units sc twice daily for table 1 guidance questions to be considered heparin for treatment of acute vte. Heparin therapeutic unfractionated heparin ufh infusion. Therapeutic dosing of unfractionated heparin neonatal. Heparin induced thrombocytopenia hit is a lifethreatening immune response to heparin and its derivatives that is associated with a high risk of thromboembolic complications. Stop heparin immediately after administering the first dose of oral anticoagulant. Continuous iv infusion of heparin at a final concentration of 5 unitsml at 1 mlhour. Practice advisories and guidelines represent the opinions of the respective authors. To assess evidence from randomized controlled trials rcts on the efficacy of low dose heparin for prolonging patency of peripheral intravenous piv catheters in the pediatric population. Low dose intravenous infusion technique with ketamine. Lowdose regimen for prevention of postoperative deep venous thrombosis and pulmonary embolism in patients greater than 40 years old undergoing major abdominothoracic surgery or. Nomogram for dvtpe, the infusion dose should be increased by 2 unitskg hour.
Patients receiving heparin intermittent iv injection. Low dose heparin continuous iv infusion via the uac with a heparin. Calculate the starting rate of the infusion mlhour. Low doses of heparin clear rapidly from plasma through a saturable cellular mechanism and the slower, nonsaturable, dose independent mechanism of renal clearance. Have second practitioner independently check original order, dose calculation, and infusion pump settings. Idarucizumab praxbind low molecular weight heparin lmwh general dosing guidelines. Initial heparin bolus dose and infusion rate 36 class iib, level c age bolus dose unitskg maximum bolus.
It has been recognized in the literature that patients in whom heparin infusion therapy is dosed according to weightbased nomograms achieve earlier therapeutic range, shorter length of stay, and fewer. Premixed heparin infusion bags of 25,000 units in 250ml sodium chloride 0. In 1992, the accp vte treatment guidelines suggested a 500010,000 unit bolus followed by a fixed heparin infusion. We searched medline, embase, cinahl, and cochrane central register of controlled trials to identify studies up to june 6, 2012. Unfractionated heparin infusion protocol objective. Intravenous unfractionated heparin standard risk protocol, or. Guidance for the practical management of the heparin ncbi. The heparin infusion comes in a 500ml bag with 25,000 units. Heparin infusion algorithms anticoagulation services. Hemorrhagic event, heparin induced thrombocytopenia.
Obtain aptt 6 hours after start of heparin infusion. At good samaritan, heparin is dosed one of two ways. Argatroban heparin infusion within 2 hours of stopping nticoagulant after 24 hours of stopping argatroban. Heparin iv infusion protocol and orderset approved changes. In this study, the montreal cognitive assessment moca was used to evaluate cognitive changes in asah patients treated with the maryland ldivh protocol compared with controls. Lowdose intravenous heparin infusion in patients with. Adult heparin infusion protocol ventura county, california. Readers are advised to analyze and apply this information in their own practices. Anticoagulation effects should be minimized within 3 hours. Heparin infusion protocols high dose protocol with no initial bolus if 65 seconds, check ptt q2h until dose of 5 mg or less per day with dosage adjustments based on serial inr determinations. If bolus dose is not to be administered or was administered previously e. Therapeutic dosing of unfractionated heparin neonatalpediatric inpatient. The optimal initial dosing of continuous infusion heparin therapy is controversial.